Reaper is the DAW for audio-engineers that is well supported on GNU/Linux.
FL Studio can works well with Wine or VM but its plugins are another story.
A few WebApps worth knowing (might not suit heavy usage):
There is also LMMS but this is more for small hobbyst rather than serious work.
You might wanna try running in a VM or WinBoat and maybe it’s worth asking on the CrossOver forum to see how well things run with CO.



You can have immuability without loosing tinkering possibilities. I do that on NixOS.
The more I learn the more I don’t want flatpaks on my machine so of course I am requiring something else than SteamOS or bazzite.